Industry 4.0 requires highly automated collaboration between different industrial systems, which must be built around a trustworthy, flexible infrastructure. Certificates are being used to establish secure connections and identify endpoints in the industrial space, including PLCs, sensors, HMIs, and gateways to name a few. We will discuss strategies for designing, deploying, and automating solutions to establish trust in the Industrial space while keeping high availability and efficiency at the forefront of the manufacturing environment.